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News - ANPA.ORG, Toronto California USA |
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| ANPA.ORG |
| Prostate Cancer Treatment May Increase Diabetes Risk |
| Date : - 31/10/2007 |
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NEW YORK (Reuters Health) Oct 31 - New research suggests that androgen-deprivation therapy (ADT) for prostate cancer can adversely affect glucose metabolism. Therefore, routine surveillance of glycemic control may be warranted, especially in obese men -- whether or not they have established diabetes.
The findings, reported in BJU International for November, also suggest that vitamin D supplementation may help protect against the development of diabetes in this patient population.
ADT is known to cause body composition changes than could influence insulin sensitivity, lead author Dr. Ithaar H. Derweesh and colleagues, from the University of Tennessee Health Science Center in Memphis, note. Whether these changes have a clinically significant effect on glucose metabolism was unclear.
The current study involved 396 patients who received ADT for prostate cancer at the researchers' center between January 1989 and July 2005. The median age at ADT initiation was 73.2 years, the median BMI was 26.7, and roughly 60% of subjects were African American.
During a median follow-up period of 60.1 months, 36 patients (11.3%) developed diabetes mellitus. Moreover, among 77 patients with preexisting diabetes, 15 (19.5%) experienced a 10% or greater rise in HbA1c levels and 22 (28.6%) experienced a similar increase in fasting glucose levels.
Multivariate analysis showed that a BMI of 30 or greater increased the odds of developing diabetes mellitus by 4.65-fold (p = 0.031). Vitamin D supplementation, by contrast, significantly reduced the risk of diabetes mellitus.
"While further investigation is required, these data support close monitoring of serum HbA1c and fasting blood glucose levels in men undergoing ADT, both in those with preexisting diabetes mellitus and those with no diabetes mellitus, but a history of obesity," the researchers conclude. |
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| Reference : - www.anpa.org |
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